Effect of periodontal treatment in patients with periodontitis and diabetes: systematic review and meta-analysis.
Level 1 - systematic review of randomized trials
Systematic review and meta-analysis of randomized controlled trials
PubMed 31939522 · doi:10.1590/1678-7757-2019-0248
What was done
A systematic review and random-effects meta-analysis searched MEDLINE (via PubMed) and the Cochrane Central Register of Controlled Trials through July 2018. Eligible studies were randomized clinical trials (RCTs) evaluating the effect of scaling and root planing (SRP) on glycated hemoglobin (HbA1c) and C-reactive protein (CRP) in patients with type 2 diabetes and periodontitis. Study quality was evaluated using the Cochrane risk of bias tool, and heterogeneity was assessed via the Q-statistic and I² test.
What was found
Nine RCTs were included. Scaling and root planing led to statistically significant reductions in HbA1c (difference in means [DM] = 0.56, 95% CI: 0.36 to 0.75; p < 0.01) and CRP (DM = 1.89, 95% CI: 1.70 to 2.08; p < 0.01). No statistical heterogeneity was detected across the included trials (I² = 0%, p > 0.05).
Why it matters
This review demonstrates that non-surgical periodontal debridement improves glycemic control and reduces systemic inflammation in patients managing both type 2 diabetes and periodontitis.
Limits
The abstract does not report the total participant sample size, specific follow-up durations, or the units of measurement for the mean difference estimates. The search was restricted to two databases up to July 2018, and detailed results of the risk of bias assessments are omitted from the abstract.
Cited by
- supports Periodontal chronic inflammation can be measured systemically as an elevation in HbA1c and C-reactive protein (CRP) levels.