Exercise-Released Myokines in the Control of Energy Metabolism.
Level 5 - mechanism / opinion, no new human data
Narrative review summarizing mechanistic pathways and organ crosstalk without systematic search methodology.
PubMed 32116795 · doi:10.3389/fphys.2020.00091
What was done
This narrative review summarizes literature regarding exercise-induced muscle contraction, the secretion of muscle-derived endocrine factors (myokines), and their physiological roles in inter-organ communication with adipose tissue, the liver, and the pancreas.
What was found
The abstract presents no quantitative data or numerical outcomes. It describes qualitative findings showing that exercise-stimulated myokines modulate adipose tissue thermogenesis and metabolism, regulate hepatic endogenous glucose production, and influence pancreatic beta-cell insulin secretion.
Why it matters
Elucidating the myokines responsible for inter-organ metabolic crosstalk outlines the molecular mechanisms linking physical activity to reduced cardiometabolic risk and highlights potential therapeutic targets for metabolic disorders.
Limits
The abstract provides no quantitative metrics, specific effect sizes, or details regarding the literature search and study selection methods. It does not differentiate between findings derived from human clinical trials and preclinical cell or animal models.
Cited by
- supports Administering an inflammatory marker without physical tissue damage can induce physiological adaptive responses.