Horowitz · Science (New York, N.Y.) 2020 · Preclinical animal experimental study with human observational comparison · n=?

Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.

Cited 514 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Preclinical animal interventional research with small human observational biomarker comparison

PubMed 32646997 · doi:10.1126/science.aaw2622 · record verified 2026-08-26

What was done

Plasma from exercised aged mice was administered to sedentary aged mice to test whether exercise benefits on neurogenesis and cognition could be transferred systemically. Investigators assessed plasma concentrations of glycosylphosphatidylinositol-specific phospholipase D1 (Gpld1), evaluated its correlation with cognitive function in aged mice, measured blood Gpld1 concentrations in active versus healthy elderly humans, and tested the effects of experimentally increasing systemic Gpld1 in aged mice.

What was found

Administration of plasma from exercised aged mice transferred the benefits of exercise on adult neurogenesis and cognitive performance to sedentary aged mice. Plasma Gpld1 concentrations increased after exercise in aged mice and correlated with improved cognitive function. Circulating Gpld1 concentrations were also elevated in active, healthy elderly humans. Experimentally increasing systemic Gpld1 in aged mice improved age-related regenerative and cognitive deficits via signaling pathways downstream of GPI-anchored substrate cleavage. No quantitative effect sizes or numerical values were reported in the abstract.

Why it matters

This study identifies a liver-to-brain systemic communication axis, suggesting that circulating liver-derived enzymes like Gpld1 mediate exercise-induced brain rejuvenation in aging.

Limits

The abstract reports no sample sizes, numerical values, or effect sizes. Most causal findings are derived exclusively from mouse models, and human data are limited to observational biomarker comparisons without demonstrated clinical efficacy.

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