Keenan · Nutrients 2020 · systematic review · n=8 studies

The Effects of Intermittent Fasting Combined with Resistance Training on Lean Body Mass: A Systematic Review of Human Studies.

Cited 63 times in the scientific literature.

Level 1 - systematic review of randomized trials

Systematic review of human studies

PubMed 32781538 · doi:10.3390/nu12082349 · record verified 2026-08-26

What was done

A systematic review following PRISMA guidelines searched MEDLINE, CINAHL, PubMed, and SportDiscus to examine the effects of intermittent fasting protocols combined with resistance training on lean body mass in previously sedentary or recreationally trained individuals. Secondary outcomes were body weight, fat mass, and protocol adherence.

What was found

Eight studies met eligibility criteria. Lean body mass was generally maintained across studies, with one study reporting a significant increase. Five of the eight studies reported significant reductions in body fat mass or body fat percentage. Quantitative effect sizes and participant numbers were not provided in the abstract.

Why it matters

This review shows that combining resistance training with intermittent fasting typically preserves lean body mass while facilitating fat loss. It helps clarify that intermittent fasting regimens do not inherently cause muscle loss when resistance training is included.

Limits

The review included only eight studies and the abstract reports no pooled quantitative data or total participant count. The abstract does not characterize the specific fasting protocols, training regimens, or dietary controls evaluated, and long-term comparisons to continuous energy restriction were not available.

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