Centofanti · Chronobiology international 2020 · crossover trial · n=6

A pilot study investigating the impact of a caffeine-nap on alertness during a simulated night shift.

Cited 26 times in the scientific literature.

Level 2 - randomized trial

Crossover laboratory trial

PubMed 32819191 · doi:10.1080/07420528.2020.1804922 · record verified 2026-08-27

What was done

In a simulated shiftwork crossover laboratory pilot study, 6 participants (4 females, aged 21-36 years) consumed either 200 mg of caffeine or decaffeinated coffee (placebo) immediately prior to a 30-minute nap opportunity at 03:30 h. Vigilant attention and subjective fatigue were assessed across the 45 minutes post-nap.

What was found

The abstract reports no numerical values, effect sizes, or statistical significance levels. It states that relative to placebo, the caffeine-nap led to improved vigilant attention and subjective fatigue in the 45 minutes post-nap.

Why it matters

This pilot provides preliminary evidence that combining caffeine intake with a night nap may counteract post-nap sleep inertia during shiftwork.

Limits

The sample size is extremely small (n = 6), the environment was a simulated laboratory rather than an operational night shift, no quantitative outcomes or variance data were provided in the abstract, and monitoring ended at 45 minutes post-nap.

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