Transendothelial transport of lipoproteins.
Level 5 - mechanism / opinion, no new human data
Narrative review of biological mechanisms without new human data
PubMed 33032832 · doi:10.1016/j.atherosclerosis.2020.09.020
What was done
Narrative review synthesizing mechanisms of transendothelial transport of low-density lipoproteins (LDL) and high-density lipoproteins (HDL) across the arterial endothelium into the subendothelial space.
What was found
No quantitative data are reported in the abstract. The review describes active, rate-limiting regulatory factors for LDL (SR-BI, activin-like kinase 1, caveolin-1) and HDL (SR-BI, ABCG1, endothelial lipase), as well as regulation by signaling molecules including estradiol, VEGF, IL-6, IL-17, purinergic signals, and sphingosine-1-phosphate.
Why it matters
Reframing lipoprotein entry into the arterial wall as an actively regulated molecular process rather than simple passive filtration points to potential therapeutic targets for preventing or treating atherosclerotic cardiovascular disease.
Limits
The abstract provides no primary human data, quantitative effect sizes, or study counts. Narrative review design without formal systematic search methodology.
Cited by
- contradicts The endothelial spaces in the inner layer of the arterial wall are large enough for almost any size or shape of LDL particle to penetrate.