Bhunia · Comprehensive reviews in food science and food safety 2013 · narrative review · n=?

Migration of Chemical Compounds from Packaging Polymers during Microwave, Conventional Heat Treatment, and Storage.

Cited 424 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Narrative review of food packaging chemistry (non-clinical, graded by design analogy)

PubMed 33412668 · doi:10.1111/1541-4337.12028 · record verified 2026-08-26

What was done

This review synthesized literature regarding the migration of chemical compounds—such as plasticizers, antioxidants, thermal stabilizers, slip compounds, and monomers—from polymeric packaging into food or food-simulating liquids during microwave heating, conventional retort processing, and storage. It also discussed analytical methods (chromatography, spectroscopy), kinetic and risk assessment modeling, and regulatory frameworks.

What was found

The abstract reports no quantitative values, ranges, or specific chemical thresholds. It identifies key determinants of migration: the nature and complexity of the food matrix, system contact time and temperature, the packaging contact layer type, and the physicochemical properties of the migrating compounds.

Why it matters

Identifying the parameters governing chemical leaching from polymers under thermal and storage stress informs risk assessment models and regulatory safety standards for food-contact materials.

Limits

This is a narrative review without a systematic search methodology, formal study quality assessment, or pooled quantitative data. No specific migrant concentrations or exposure limits are reported in the abstract.

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