Jagim · Nutrients 2021 · narrative review · n=?

Creatine Supplementation in Children and Adolescents.

Cited 47 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Narrative review without systematic search or meta-analysis

PubMed 33670822 · doi:10.3390/nu13020664 · record verified 2026-08-26

What was done

The authors conducted a narrative review synthesizing literature on the rationale, prevalence of use, athletic performance benefits, clinical applications (such as neuromuscular and metabolic disorders), and safety profile of creatine supplementation in children and adolescents.

What was found

The abstract reports no numerical data or effect sizes. It notes that creatine is commonly used by adolescents and that limited studies in adolescent athletes generally report improvements in ergogenic outcomes without ergolytic effects. Available reports also consistently indicate an absence of adverse events in pediatric populations.

Why it matters

This review highlights that while creatine is well-studied in adults, preliminary evidence supports its therapeutic and performance applications in younger populations, defining safety boundaries and identifying research gaps.

Limits

As a narrative review, it lacks systematic search methodology and quantitative meta-analysis. The abstract provides no specific statistics, sample sizes, or dosage details. Pediatric evidence remains limited in scope compared to adult data.

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