Thyroid hormone action in epidermal development and homeostasis and its implications in the pathophysiology of the skin.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic and observational literature without systematic review methodology
PubMed 33683663 · doi:10.1007/s40618-020-01492-2
What was done
Narrative review summarizing clinical epidermal manifestations linked to thyroid diseases and examining the molecular mechanisms by which thyroid hormones regulate keratinocyte proliferation and differentiation, drawing on findings from mouse models of altered thyroid hormone metabolism.
What was found
The abstract reports no quantitative data or statistical estimates. It reports that thyroid hormones regulate skin homeostasis, that thyroiditis is clinically associated with alopecia, dermatitis, and vitiligo, and that Graves' disease is frequently correlated with alopecia and eczema.
Why it matters
It highlights the role of peripheral thyroid hormone action in cutaneous biology and outlines pathways that may explain dermatologic manifestations seen in thyroid disorders.
Limits
This is a narrative review with no primary patient data, sample sizes, or systematic search methodology reported in the abstract. Clinical associations are descriptive rather than causal, and mechanistic insights rely heavily on mouse models.
Cited by
- context Low thyroid function impairs keratinocyte turnover, leading to cystic acne, keratosis pilaris, rough skin, and ingrown toenails.