Cai · GMS infectious diseases 2021 · Narrative review with systematic search · n=?

Recurrent uncomplicated urinary tract infections: definitions and risk factors.

Cited 37 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Narrative review and guideline synthesis without meta-analytic pooling

PubMed 34113535 · doi:10.3205/id000072 · record verified 2026-08-27

What was done

The authors reviewed international clinical guidelines and conducted a literature search across Medline, Cochrane, and Embase to summarize definitions, clinical burden, and risk factors for recurrent uncomplicated urinary tract infections.

What was found

The abstract reports no numerical data, effect estimates, or patient counts. It qualitatively identifies key risk factors including sexual intercourse, spermicide use, a new sexual partner, maternal history of UTI, childhood UTI history, and treatment of asymptomatic bacteriuria. Additional identified factors include low fluid intake, habitual or post-coital delayed urination, wiping back-to-front, douching, occlusive underwear, and irregular bowel function.

Why it matters

Identifying modifiable behavioral factors and non-modifiable historical risks helps clinicians tailor prevention counseling and identify high-risk patients who may benefit from structured prophylactic strategies.

Limits

The abstract provides no study counts, sample sizes, search dates, screening criteria, or quantitative effect sizes. Risk factors reflect observational associations that cannot establish causality directly from this summary.

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