An overview of diagnosis and management of drug-induced hypomagnesemia.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic search methodology
PubMed 34278747 · doi:10.1002/prp2.829
What was done
This narrative review evaluated available literature on the pathogenetic mechanisms, diagnosis, and management of drug-induced hypomagnesemia, with a focus on intestinal and renal magnesium transporters.
What was found
No quantitative findings or effect sizes were reported in the abstract. The review notes that culprit medications associated with hypomagnesemia include proton pump inhibitors, diuretics, calcineurin inhibitors, antineoplastics (cisplatin, cetuximab), and antibiotics (aminoglycosides, amphotericin B), and highlights associations between chronic hypomagnesemia, cardiovascular disease, diabetes mellitus, and secondary electrolyte disturbances.
Why it matters
It consolidates understanding of how widely prescribed medications interfere with magnesium handling, assisting clinicians in recognizing and addressing secondary electrolyte imbalances.
Limits
This is a non-systematic narrative review without predefined study inclusion criteria, risk-of-bias evaluation, or pooled numerical estimates. The abstract provides no specific incidence rates, comparative drug risks, or clinical trial endpoints.
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