Marazziti · Advances in experimental medicine and biology 2021 · narrative review · n=?

The Science of Love: State of the Art.

Cited 20 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Narrative review and theoretical model with no primary human trial data or systematic search.

PubMed 34453303 · doi:10.1007/978-3-030-74046-7_16 · record verified 2026-08-29

What was done

This paper reviews the neuroscientific literature on love and presents a conceptual framework describing the neural substrates and neurochemical shifts that occur across distinct phases of romantic bonding.

What was found

The abstract reports no empirical data, sample sizes, or numerical outcomes. It describes a theoretical framework where early romantic love involves limbic fear/anxiety circuit activation, increased monoamines, and decreased serotonin, while the second stage (attachment) involves oxytocin, vasopressin, and neurotrophins.

Why it matters

The paper outlines how distinct neurobiological systems involved in bonding and attachment may mediate the physiological and psychological benefits associated with love.

Limits

The paper provides no primary empirical data or systematic review methodology. The proposed neurobiological models are explicitly acknowledged by the authors as speculative, limited by scarce data, and oversimplified.

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