The Histaminergic System in Neuropsychiatric Disorders.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing preclinical and clinical mechanism-based literature without systematic review methods.
PubMed 34572558 · doi:10.3390/biom11091345
What was done
This narrative review summarizes literature on the mammalian central histaminergic system, detailing the distribution of histaminergic neurons, histamine receptor subtypes, and downstream intracellular pathways. It reviews preclinical and clinical evidence addressing cell-type-specific and circuit-level roles of histamine in narcolepsy, schizophrenia, Alzheimer's disease, Tourette's syndrome, and Parkinson's disease.
What was found
The abstract reports no quantitative data, statistics, or effect sizes. It qualitatively describes the involvement of brain histamine circuits in regulating wakefulness, appetite, cognition, and arousal, and notes alterations in these pathways across multiple neuropsychiatric disorders.
Why it matters
It organizes current understanding of central histamine circuitry across several major neurological and psychiatric disorders, highlighting histaminergic targets for therapeutic investigation.
Limits
As a narrative review, it presents no original empirical data and lacks a systematic search strategy, explicit study selection criteria, or formal risk-of-bias grading. Quantitative results and sample sizes across the discussed conditions are not detailed in the abstract.
Cited by
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