Age-Dependent Decline of NAD + -Universal Truth or Confounded Consensus?
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing cross-species literature without systematic review methodology
PubMed 35010977 · doi:10.3390/nu14010101
What was done
The authors reviewed published literature measuring NAD+ levels during aging across multiple species (yeast, C. elegans, rat, mouse, monkey, and human) to evaluate whether empirical data support a universal, systemic decline with age.
What was found
The abstract reports no numerical values or effect sizes. The authors found that evidence for a global age-related decline in NAD+ is very limited and often restricted to single tissues or cell types, with human aging trajectories remaining particularly poorly characterized.
Why it matters
This paper challenges the widespread assumption of universal NAD+ depletion during aging, highlighting that therapeutic interventions targeting global NAD+ restoration may rest on overgeneralized findings.
Limits
The abstract provides no study counts, search parameters, or quantitative synthesis. The reviewed evidence base is limited by a lack of multi-tissue analyses and an absence of large longitudinal human cohorts.
Cited by
- partial NAD levels decline across human development into adulthood.