Insulin: The master regulator of glucose metabolism.
Level 5 - mechanism / opinion, no new human data
Narrative review of physiologic and molecular mechanisms with no systematic search or primary human data.
PubMed 35066003 · doi:10.1016/j.metabol.2022.155142
What was done
This is a narrative review describing the integrated physiologic impact and molecular basis of insulin's actions across muscle, liver, adipocytes, and vasculature following glucose or mixed meal ingestion.
What was found
The abstract reports no quantitative data or statistics. It summarizes that postprandial insulin secretion coordinates glucose homeostasis by suppressing endogenous glucose production, stimulating tissue glucose uptake, inhibiting lipolysis to lower plasma free fatty acids, and causing muscle vasodilation to facilitate glucose disposal.
Why it matters
It provides a consolidated framework of multi-organ insulin physiology essential for understanding healthy metabolism and insulin-resistant states.
Limits
As a narrative review, it presents no original empirical data, quantitative synthesis, or systematic search methodology.
Cited by
- context Skeletal muscle accounts for roughly 80% of glucose uptake during glucose clearance.