Parental overnutrition by carbohydrates in developmental origins of metabolic syndrome.
Level 5 - mechanism / opinion, no new human data
Narrative review of preclinical and animal research without systematic methodology
PubMed 35199545 · doi:10.33549/physiolres.934806
What was done
This narrative review synthesized literature examining the effects of maternal carbohydrate overnutrition (fructose, sucrose, glucose) on metabolic syndrome programming and nutri-epigenomic interactions in offspring.
What was found
No quantitative data, sample sizes, or effect estimates are provided in the abstract. Qualitatively, maternal carbohydrate overnutrition typically increases offspring body weight and hepatic lipid content, though sucrose administration in several rat models reportedly showed favorable metabolic outcomes.
Why it matters
The review summarizes potential epigenetic mechanisms by which maternal sugar overconsumption programs metabolic disease across generations, emphasizing the moderating role of genomic background.
Limits
The abstract contains no quantitative metrics or systematic review methodology. Reported evidence is derived largely from animal models with substantial discrepancies in experimental design, and human clinical relevance remains unestablished.
Cited by
- supports Animal studies demonstrate that high maternal sugar intake during pregnancy triggers epigenetic changes in fetal DNA that promote fat storage.