Creatine as a Promising Component of Paternal Preconception Diet.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic bioenergetics and preliminary literature without systematic review methodology.
PubMed 35276945 · doi:10.3390/nu14030586
What was done
This narrative mini-review evaluated the role of creatine in spermatozoa bioenergetics, reviewed observational associations between creatine levels and semen quality parameters in men, and summarized available interventional evidence examining creatine supplementation for sperm viability.
What was found
The abstract reports no numerical findings, sample sizes, or effect estimates. It qualitatively describes creatine as a key contributor to sperm energy metabolism and a promising candidate nutrient for male reproductive health.
Why it matters
Paternal preconception nutrition is increasingly recognized as a modifiable factor in reproductive health. Understanding creatine bioenergetics in spermatozoa helps identify biological targets for future clinical trials on male subfertility.
Limits
This is a non-systematic narrative mini-review providing no quantitative data or meta-analytic pooling in the abstract. Interventional evidence in humans is limited, and specific dosages, efficacy endpoints, and adverse effects are not detailed.
Cited by
- supports Research by Sergej Ostojic shows creatine supplementation does not downregulate sperm production and instead improves sperm vitality and motility.