Immune-Mediated Association Between Celiac Disease and Sensorineural Hearing Loss: A Systematic Narrative Review.
Level 3 - non-randomized controlled study
Systematic review of predominantly observational studies without meta-analysis
PubMed 35550535 · doi:10.5152/tjg.2022.21554
What was done
The authors searched the PubMed database to identify studies investigating the relationship between sensorineural hearing loss and celiac disease in children and adults. Case reports and review articles were excluded. From 32 initial search results, 10 studies met the inclusion criteria for this systematic narrative review.
What was found
The abstract reports no numerical data, effect sizes, or participant totals. It notes that several included studies postulated the presence of subclinical hearing loss in children with celiac disease, but overall findings remain inconclusive regarding a definitive link or underlying pathogenetic mechanisms.
Why it matters
This review aggregates existing literature on sensorineural hearing loss as a potential extra-intestinal manifestation of celiac disease, discussing the rationale for early hearing screening in pediatric patients.
Limits
The literature search was restricted to a single database (PubMed). The abstract provides no quantitative meta-analysis, sample size details, or risk-of-bias assessments, and notes that the current evidence is insufficient to clarify the association.
Cited by
- context Individuals with autoimmune conditions such as rheumatoid arthritis or celiac disease have an increased risk of hearing loss due to inner ear injury and fixation of middle ear ossicular joints.