Shailendra · American journal of preventive medicine 2022 · systematic review and meta-analysis · n=10 studies

Resistance Training and Mortality Risk: A Systematic Review and Meta-Analysis.

Cited 96 times in the scientific literature.

Level 1 - systematic review of randomized trials

Systematic review and meta-analysis of prospective cohort studies

PubMed 35599175 · doi:10.1016/j.amepre.2022.03.020 · record verified 2026-08-31

What was done

A systematic review and meta-analysis following PRISMA guidelines was conducted across six databases (MEDLINE, Embase, Emcare, SPORTDiscus, The Cochrane Library, and SCOPUS) from inception to June 6, 2021. Eligible studies assessed resistance training as an exposure and all-cause, cardiovascular disease (CVD), or cancer mortality as outcomes among nonclinical adults (aged ≥18 years) in English-language publications.

What was found

Ten studies were included. Compared with no resistance training, any resistance training reduced all-cause mortality risk by 15% (RR = 0.85; 95% CI: 0.77, 0.93; 6 studies), CVD mortality by 19% (RR = 0.81; 95% CI: 0.66, 1.00; 4 studies), and cancer mortality by 14% (RR = 0.86; 95% CI: 0.78, 0.95; 5 studies). In dose-response meta-analysis (4 studies), a nonlinear relationship was observed with a maximum all-cause mortality reduction of 27% at around 60 minutes per week (RR = 0.74; 95% CI: 0.64, 0.86), with risk reductions diminishing at higher volumes.

Why it matters

This review quantitatively demonstrates that approximately one hour per week of resistance training is associated with substantial reductions in all-cause, CVD, and cancer mortality, while highlighting potential diminishing benefits at higher volumes.

Limits

The review included only 10 studies overall and only 4 for the dose-response analysis. The included studies are observational cohorts, susceptible to residual confounding and exposure misclassification. The abstract lacks data on participant numbers, exercise intensity, specific modalities, and excluded non-English literature.

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