Creatine supplementation for older adults: Focus on sarcopenia, osteoporosis, frailty and Cachexia.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic search or meta-analysis methodology
PubMed 35688360 · doi:10.1016/j.bone.2022.116467
What was done
This narrative review summarizes existing research on the effects of creatine monohydrate supplementation—primarily when combined with resistance training—on muscle and bone health indices (including bone turnover markers) in aging populations, and evaluates the rationale for its application in sarcopenia, osteoporosis, frailty, and cachexia.
What was found
The abstract provides no quantitative data, effect sizes, or specific statistical findings. It reports qualitatively that creatine monohydrate supplementation, particularly when paired with resistance training, demonstrates favorable effects on measures of aging muscle and bone.
Why it matters
It outlines the rationale for combining creatine supplementation with exercise interventions to mitigate age-related musculoskeletal deterioration and frailty.
Limits
This is an unsystematic narrative review that does not detail search methods, include risk-of-bias evaluations, or provide quantitative synthesis. No primary trial sample sizes or empirical endpoints are reported in the abstract.
Cited by
- context Creatine stimulates osteoblasts and reduces osteoclast activity, favorably altering bone turnover similarly to bisphosphonates.