LncRNA, an Emerging Approach for Neurological Diseases Treatment by Regulating Microglia Polarization.
Level 5 - mechanism / opinion, no new human data
Narrative review of mechanistic and preclinical literature with no original human clinical data.
PubMed 35860297 · doi:10.3389/fnins.2022.903472
What was done
The authors synthesized literature on the mechanistic roles of long non-coding RNAs (lncRNAs) in regulating microglial polarization (M1 pro-inflammatory versus M2 anti-inflammatory phenotypes) and evaluated their potential therapeutic implications for neurological disorders.
What was found
The abstract describes qualitative molecular pathways rather than quantitative results. It notes that lncRNAs participate in microglial gene expression through transcriptional regulation and downstream miRNA sponging, influencing downstream processes including neuronal apoptosis, synaptic plasticity, blood-brain barrier integrity, ferroptosis resistance, and astrocyte signaling. No numerical data or effect sizes are provided.
Why it matters
This review outlines theoretical molecular targets for modulating neuroinflammation and microglial activation in central nervous system pathologies.
Limits
As a narrative review, it lacks a systematic literature search, quantitative meta-analytic data, and risk-of-bias evaluation. The findings reflect preclinical and cellular mechanisms with no direct human clinical evidence presented.
Cited by
- supports M1-activated microglia destroy synapses, generate neuroinflammation, impair neuronal function, and increase the permeability of the blood-brain barrier.