Effects of glyphosate and glyphosate-based herbicides like Roundup™ on the mammalian nervous system: A review.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing preclinical, cellular, and observational studies without systematic review methodology.
PubMed 35868581 · doi:10.1016/j.envres.2022.113933
What was done
The authors conducted a narrative literature review examining published evidence regarding the effects of glyphosate and glyphosate-based herbicides (such as Roundup) on mammalian nervous system function, cellular pathways, and related neurological disorders.
What was found
The abstract provides no numerical data, odds ratios, or effect sizes. It qualitatively reports that exposure to glyphosate-based herbicides is associated with an increased risk of Parkinson's disease, neuronal cell death in the substantia nigra, elevated risk of autism, altered synaptic transmission in cellular and animal models, oxidative stress with mitochondrial dysfunction, and disruption of the gut microbiome.
Why it matters
This review aggregates evidence suggesting that widespread agricultural use of glyphosate-based herbicides may pose risks to neurodevelopment and mammalian brain health beyond established concerns regarding carcinogenicity and endocrine disruption.
Limits
The abstract does not describe systematic review methodology, study selection criteria, or quantitative synthesis. No sample sizes, exposure doses, or statistical metrics are reported. Findings heavily rely on cellular, animal, and observational evidence, which limits direct causal inference regarding human exposure levels.
Cited by
- supports Glyphosate functions as a mitochondrial toxin.