Comparative Impact of Various Exercises on Circulating Irisin in Healthy Subjects: A Systematic Review and Network Meta-Analysis.
Level 1 - systematic review of randomized trials
Systematic review and network meta-analysis
PubMed 35910840 · doi:10.1155/2022/8235809
What was done
The authors searched Cochrane Library, PubMed, ISI, Scopus, Embase, and Pedro up to September 2021 for studies evaluating the effects of acute and chronic exercise modalities (aerobic, anaerobic, and resistance training) on circulating plasma or serum irisin levels in healthy participants. A random-effects network meta-analysis was performed using Hedge's g standardized mean difference (SMD) and P-score rankings.
What was found
Across 16 included studies (6 acute with 175 participants; 10 chronic with 433 participants), acute aerobic exercise (Hedge's g = 0.23; 95% CI: -0.58, 1.03) and acute anaerobic exercise (Hedge's g = 0.12; 95% CI: -0.45, 0.70) showed non-statistically significant increases relative to control. For chronic exercise, resistance training ranked superior to anaerobic and aerobic training (P score = 0.632). Comparing acute and chronic modalities, acute training ranked highest overall for improving irisin levels (P score = 0.721).
Why it matters
This review compares the relative effectiveness of different exercise types and timeframes on circulating irisin, identifying acute bouts and chronic resistance training as the top-ranked modalities.
Limits
The total sample size was modest (608 participants across 16 studies), and effect estimates for acute exercise had wide confidence intervals spanning zero. The abstract omits effect sizes and confidence intervals for the chronic exercise comparisons, as well as details on exercise intensity, participant demographics, and blood sampling timing.
Cited by
- supports Exercise stimulates the production of irisin, which upregulates and creates more brown adipose tissue.