Cellular and Molecular Regulation of Exercise-A Neuronal Perspective.
Level 5 - mechanism / opinion, no new human data
Narrative review describing cellular and molecular mechanisms without systematic review methodology or new clinical data.
PubMed 35986789 · doi:10.1007/s10571-022-01272-x
What was done
This narrative review synthesized literature on the cellular and molecular mediators of exercise (the exercise responsome), focusing on peripheral exerkines (such as FNDC5/irisin, Cathepsin B, adiponectin, and IL-6) and downstream signaling molecules (including AMPK, SIRT1, PGC1α, BDNF, IGF-1, and VEGF) that affect the central nervous system.
What was found
The abstract provides no empirical numbers or quantitative findings. It summarizes mechanistic pathways through which exercise-induced exerkines cross the blood-brain barrier and modulate signaling associated with neurogenesis, synaptic plasticity, energy metabolism, and neuroprotection.
Why it matters
It outlines the multi-systemic molecular pathways linking peripheral tissue adaptations from exercise to brain function and potential neurodegenerative disease resistance.
Limits
As a narrative review, it lacks a systematic literature search, risk-of-bias assessment, or quantitative pooling. The abstract reports no human sample sizes, effect sizes, or specific exercise dose-response parameters.
Cited by
- supports IGF-1 and brain-derived neurotrophic factor (BDNF) cross or act across the blood-brain barrier to promote the growth of new brain cells.