Epidemiology and Clinical Features of Heart Failure with Preserved Ejection Fraction.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic search or meta-analysis
PubMed 35991117 · doi:10.15420/cfr.2022.06
What was done
This narrative review summarizes existing literature on the epidemiology, clinical features, risk factors, and phenotypic variations (by age, comorbidities, race/ethnicity, and geography) of heart failure with preserved ejection fraction (HFpEF).
What was found
The abstract reports that HFpEF represents more than half of all heart failure cases in ageing societies. It notes a shift from viewing HFpEF solely as a condition of elderly, hypertensive women toward recognizing heterogeneity across clinical phenotypes and pathophysiological mechanisms. No additional quantitative data or effect estimates are reported in the abstract.
Why it matters
Understanding the phenotypic and demographic variations in HFpEF provides a clinical basis for earlier diagnosis and targeting modifiable risk factors for prevention.
Limits
As a narrative review, it lacks a systematic search protocol, quality assessment of included studies, or pooled statistical analysis. No specific sample sizes or quantitative metrics are detailed in the abstract.
Cited by
- supports Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of all heart failure cases.