Ben Simon · PLoS biology 2022 · Multi-method experimental, prospective observational, and natural experiment study · n=>3,000,000 donations (cohort sample sizes not stated in abstract)

Sleep loss leads to the withdrawal of human helping across individuals, groups, and large-scale societies.

Cited 45 times in the scientific literature.

Level 3 - non-randomized controlled study

Multi-method study combining an experimental sleep deprivation trial with fMRI, a prospective daily-tracking cohort, and an observational natural experiment; graded by design analogy.

PubMed 35998121 · doi:10.1371/journal.pbio.3001733 · record verified 2026-08-31

What was done

Across three sub-studies, researchers examined the effect of sleep loss on prosocial helping: (1) an individual-level experiment testing the effect of 1 night of total sleep deprivation along with fMRI imaging of the social cognition brain network; (2) an ecological group study tracking night-to-night sleep variations and next-day interpersonal helping decisions; and (3) a population-level natural experiment assessing the effect of 1 hour of lost sleep opportunity during the Daylight Saving Time transition across more than 3 million charitable donations.

What was found

The abstract reports no numerical values, effect sizes, or confidence intervals. Qualitatively, 1 night of sleep loss led to reduced interpersonal helping and deactivation of social cognition brain network nodes. Night-to-night sleep reductions predicted lower next-day helping in daily interactions. The 1-hour sleep loss from Daylight Saving Time transition predicted a reduction in real-world charitable donation giving.

Why it matters

This work links neural mechanisms of social cognition to real-world population behaviors, demonstrating that both acute sleep deprivation and minor societal-level sleep loss can impair altruism and human cooperation.

Limits

The abstract does not provide exact participant sample sizes for the fMRI or daily tracking cohorts, nor does it provide quantitative effect sizes or p-values. The Daylight Saving Time analysis relies on aggregate observational donation data, which may be susceptible to unmeasured temporal confounders.

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