Ketogenic Diet Benefits to Weight Loss, Glycemic Control, and Lipid Profiles in Overweight Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trails.
Level 1 - systematic review of randomized trials
Systematic review and meta-analysis of randomized controlled trials
PubMed 36012064 · doi:10.3390/ijerph191610429
What was done
Authors systematically searched Embase, PubMed, Web of Science, and Cochrane Library databases for randomized controlled trials evaluating the effects of a ketogenic diet on body weight control, glycemic management, and lipid profiles in overweight patients with type 2 diabetes mellitus. Eight randomized controlled trials were identified and included in the meta-analysis.
What was found
The ketogenic diet demonstrated statistically significant benefits across several outcomes: - Body weight loss: SMD -5.63 (p = 0.008) - Waist circumference reduction: SMD -2.32 (p = 0.04) - Glycated hemoglobin reduction: SMD -0.38 (p = 0.0008) - Triglyceride reduction: SMD -0.36 (p = 0.0001) - High-density lipoprotein increase: SMD 0.28 (p = 0.003)
Why it matters
Synthesizes randomized controlled trial evidence indicating that ketogenic diets can concurrently improve weight, waist circumference, glycemic markers, and select lipid parameters in overweight individuals with type 2 diabetes.
Limits
The review is limited to eight trials. The abstract does not report the total participant count, intervention duration, adherence levels, control diet compositions, or effects on low-density lipoprotein cholesterol, total cholesterol, adverse events, or long-term sustainability.
Cited by
- supports A ketogenic diet is an effective treatment for diabetes and for lowering elevated blood sugar levels.