Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials.
Level 1 - systematic review of randomized trials
Systematic review and meta-analysis of randomized controlled trials
PubMed 36013514 · doi:10.3390/medicina58081047
What was done
Researchers conducted a systematic review and meta-analysis following PRISMA guidelines searching PubMed, Scopus, Web of Science, Cochrane, Ovid/Embase, and Google Scholar. They evaluated randomized clinical trials examining the effect of Eurycoma longifolia as a monotherapy on serum total testosterone levels in men.
What was found
Nine studies were included in the systematic review, with five randomized clinical trials pooled for meta-analysis. A random-effects model showed a significant increase in total testosterone levels in men receiving Eurycoma longifolia supplementation compared to controls (SMD = 1.352, 95% CI 0.565 to 2.138, p = 0.001), an effect also confirmed in the hypogonadism subgroup.
Why it matters
This review provides quantitative pooled evidence that Eurycoma longifolia can elevate total testosterone levels in both healthy and hypogonadal males, supporting its potential use as a non-pharmaceutical option.
Limits
The total number of participants is not reported in the abstract, and the quantitative analysis includes only five RCTs. The abstract does not provide details on specific dosages, treatment durations, formulation standardization, or adverse effect profiles.
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