Dietary consumption of cruciferous vegetables and bladder cancer risk: A systematic review and meta-analysis.
Level 3 - non-randomized controlled study
Systematic review and meta-analysis of observational cohort studies.
PubMed 36061884 · doi:10.3389/fnut.2022.944451
What was done
A systematic review and meta-analysis of cohort studies was conducted via PubMed and EMBASE searches through March 2022 to examine the relationship between cruciferous vegetable consumption and bladder cancer risk. The authors calculated pooled relative risks (RRs) comparing highest versus lowest intake categories and conducted linear dose-response meta-analyses for intake increments of 10 g/day and 1 serving/week.
What was found
Highest versus lowest cruciferous vegetable intake was not significantly associated with reduced bladder cancer risk (RR = 0.92, 95% CI 0.80–1.06). Linear dose-response meta-analysis showed no statistically significant reduction per 10 g/day increment (P = 0.106) or 1 serving/week increment (P = 0.147). No significant publication bias was detected (Begg's P = 0.386; Egger's P = 0.253).
Why it matters
Synthesizing available prospective cohort evidence indicates that dietary cruciferous vegetable consumption does not show a statistically significant protective effect against bladder cancer.
Limits
The abstract does not state the number of included studies or total sample size. The analysis is limited to observational cohort data subject to potential dietary misclassification, residual confounding, and heterogeneity in preparation and intake measurements.
Cited by
- contradicts Epidemiological studies show that dietary intake of cruciferous vegetables, such as broccoli, is associated with a reduced risk of bladder cancer and bladder cancer recurrence.