The effects of resistance exercise on body composition and physical function in prostate cancer patients undergoing androgen deprivation therapy: an update systematic review and meta-analysis.
Level 1 - systematic review of randomized trials
Systematic review and meta-analysis of clinical trials
PubMed 36382930 · doi:10.1080/13685538.2022.2146670
What was done
A systematic review and meta-analysis searched PubMed, Embase, Cochrane, and Web of Science through March 31, 2022. The review evaluated the effects of resistance exercise on body composition and physical function in prostate cancer patients receiving androgen deprivation therapy (ADT).
What was found
Resistance exercise produced statistically significant improvements in lean body mass (MD: 1.12, 95% CI [0.48, 1.76], p < 0.01), body fat percentage (MD: -1.12, 95% CI [-1.99, -0.24], p < 0.05), appendicular skeletal mass (MD: 0.74, 95% CI [0.45, 1.03], p < 0.01), leg press strength (MD: 77.95, 95% CI [38.90, 117.00], p < 0.01), and stair climb time (MD: -0.30, 95% CI [-0.49, -0.12], p < 0.01). Improvements in body fat mass (MD: -0.21, 95% CI [-0.79, 0.37], p > 0.05), 400 m walk time (MD: -21.74, 95% CI [-45.53, 2.05], p > 0.05), and timed up-and-go test (MD: -0.50, 95% CI [-1.03, 0.03], p > 0.05) did not reach statistical significance. Subgroup analysis showed greater body composition improvements with training durations ≥ 6 months, immediate exercise initiation upon starting ADT, and training intensities of 8–12 repetition maximum (RM).
Why it matters
Resistance exercise directly counters sarcopenia and functional decline associated with androgen deprivation therapy, supporting its structured use during prostate cancer treatment.
Limits
The abstract does not report the number of included studies, total participant sample size, study design breakdown of included trials, effect size measurement units, or heterogeneity and risk of bias assessments.
Cited by
- supports Weight training interventions in prostate cancer patients undergoing androgen deprivation therapy significantly improve muscle mass, muscular strength, fatigue, and energy.