Resistance Exercise Training Increases Muscle Mass and Strength in Prostate Cancer Patients on Androgen Deprivation Therapy.
Level 2 - randomized trial
Randomized trial of exercise with protein vs. placebo, though the usual care comparator was a separate non-randomized cohort.
PubMed 36534950 · doi:10.1249/MSS.0000000000003095
What was done
Sixty prostate cancer patients receiving androgen deprivation therapy (ADT) were randomly assigned to 20 weeks of resistance exercise training with either 31 g whey protein (EX + PRO, n = 30) or placebo (EX + PLA, n = 30), taken post-exercise and nightly before sleep. A separate control group (CON, n = 36) received usual care only. At baseline and 20 weeks, body composition (DXA), muscle mass (CT scan), muscle strength (1RM tests), physical performance (Timed Up and Go, 30-Second Chair Stand, Stair Climb), aerobic capacity (cardiopulmonary exercise test), and habitual dietary intake were measured.
What was found
The abstract reports directional outcomes without providing specific numerical values or effect sizes: - Muscle mass and muscle strength increased in EX + PRO and EX + PLA, but decreased in CON. - Total fat mass and fat percentage increased in EX + PRO and CON, but not in EX + PLA. - Physical performance did not significantly change over time in any group. - Aerobic capacity was maintained in EX + PLA, but decreased in EX + PRO and CON. - Habitual protein intake (excluding supplements) averaged >1.0 g/kg/day with no differences between groups or over time.
Why it matters
Resistance exercise mitigates muscle mass and strength loss associated with ADT in prostate cancer patients. Additional whey protein supplementation provides no clear additive benefit when baseline habitual protein intake is already adequate.
Limits
The control group was non-randomized (separate usual care cohort). The abstract provides no exact numerical values, effect sizes, or confidence intervals for the primary outcomes. Findings may not generalize to patients with baseline protein malnutrition.
Cited by
- supports Prostate cancer patients receiving androgen deprivation therapy who engaged in resistance exercise twice a week increased muscle mass and strength compared to controls who lost muscle mass.
- partial The adverse muscular side effects of androgen deprivation therapy (ADT) in prostate cancer patients can be fully overcome with resistance exercise, allowing patients to increase muscle mass and strength.