Fabero-Garrido · Journal of clinical medicine 2022 · systematic review and meta-analysis · n=14 studies

Effects of Low-Load Blood Flow Restriction Resistance Training on Muscle Strength and Hypertrophy Compared with Traditional Resistance Training in Healthy Adults Older Than 60 Years: Systematic Review and Meta-Analysis.

Cited 23 times in the scientific literature.

Level 1 - systematic review of randomized trials

Systematic review and meta-analysis of comparative trials

PubMed 36556004 · doi:10.3390/jcm11247389 · record verified 2026-08-30

What was done

Authors conducted a systematic review and meta-analysis searching MEDLINE, PEDro, CINAHL, Web of Science, ScienceDirect, Scopus, and CENTRAL. They evaluated the effects of low-load blood flow restriction (LL-BFR) resistance training compared with traditional high-load (HL) and low-load (LL) resistance training on muscle strength and hypertrophy in healthy adults older than 60 years, including the effect of cuff pressure.

What was found

Fourteen studies were included in the analysis: - HL vs. LL-BFR: HL training resulted in slightly greater muscle strength increases (8 studies; SMD -0.23, 95% CI [-0.41, -0.05]), but no significant difference in muscle hypertrophy (6 studies; SMD 0.08, 95% CI [-0.22, 0.38]). - LL-BFR vs. traditional LL: LL-BFR yielded superior increases in strength (7 studies; SMD 0.44, 95% CI [0.28, 0.60]) and hypertrophy (2 studies; SMD 0.51, 95% CI [0.06, 0.96]). - Cuff pressure: Higher cuff pressure enhanced strength gains compared with traditional LL, but not compared with HL training.

Why it matters

LL-BFR offers an effective alternative to traditional heavy lifting in older adults, matching the hypertrophy benefits of high-load training and exceeding traditional low-load regimens.

Limits

The total number of participants is not reported in the abstract. Evidence for hypertrophy in the LL-BFR versus traditional LL comparison is based on only two studies. Long-term functional outcomes, adherence, and adverse events were not detailed.

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