Circadian Control of Gastrointestinal Motility.
Level 5 - mechanism / opinion, no new human data
Narrative review of mechanistic pathways without systematic synthesis or primary human clinical data.
PubMed 36587158 · doi:10.1007/978-3-031-05843-1_18
What was done
This narrative review summarizes literature on endogenous circadian rhythms in the gastrointestinal (GI) tract. It outlines how the central circadian pacemaker in the suprachiasmatic nucleus (SCN)—entrained primarily by light—and peripheral molecular clocks—entrained by feeding—interact to regulate GI function and motility.
What was found
The abstract reports no numerical data or quantitative findings. It describes mechanistic pathways: the SCN regulates peripheral organs via melatonin and corticosteroids, and feeding cycles entrain peripheral gut clocks, coordinating GI motility with food availability and showing alterations during circadian disruption.
Why it matters
It outlines how central and peripheral clock synchronization governs gut motility, helping frame how circadian rhythm disruption might impair digestive physiology.
Limits
The abstract describes a narrative overview without primary empirical data, sample sizes, quantitative effect estimates, or a systematic search methodology.
Cited by
- supports The primary inputs driving the suprachiasmatic nucleus circadian clock are ocular sunlight exposure, physical activity, meal timing, and social engagement.