Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals.
Level 5 - mechanism / opinion, no new human data
Bench and animal research with no human data
PubMed 36599299 · doi:10.1016/j.cmet.2022.12.006
What was done
Mice were subjected to isocaloric ad libitum feeding or time-restricted feeding of a western diet. Investigators collected samples from 22 organs and brain regions every 2 hours over a 24-hour period to analyze diurnal transcriptome changes.
What was found
Time-restricted feeding significantly altered gene expression, with nearly 80% of all genes exhibiting differential expression or rhythmicity in at least one tissue. Functional annotation demonstrated tissue- and pathway-specific effects. No other quantitative figures or statistical values were reported in the abstract.
Why it matters
This work establishes a comprehensive multi-tissue atlas of diurnal gene expression shifts under time-restricted feeding, providing mechanistic hypotheses for human time-restricted eating.
Limits
The study was conducted entirely in mice fed a western diet, so findings may not directly translate to human physiology or other dietary contexts. The abstract does not report the total animal sample size (n) nor direct physiological or functional phenotypic outcomes.
Cited by
- supports Restricting animal food intake to a 9- to 12-hour window improves glucose metabolism, lipid profiles, and cholesterol, increases lean muscle mass, decreases fat mass, and reduces fatty liver.
- supports Time-restricted eating reduces the expression of the gastric proton pump in the mouse gut.