Alcohol, Resistance Exercise, and mTOR Pathway Signaling: An Evidence-Based Narrative Review.
Level 5 - mechanism / opinion, no new human data
Narrative review of mechanistic and experimental literature without a systematic review protocol
PubMed 36671386 · doi:10.3390/biom13010002
What was done
This narrative review synthesized current literature examining the independent and interactive effects of acute alcohol ingestion and resistance exercise on skeletal muscle mammalian/mechanistic target of rapamycin complex 1 (mTORC1) pathway signaling.
What was found
The abstract provides no quantitative data or statistical estimates. It reports that acute alcohol inhibits mTORC1 pathway signaling whereas resistance exercise activates it. Anabolic stimuli may partially attenuate or rescue alcohol-induced pathway inhibition, though outcomes vary across experimental models, sex, nutritional state, training background, and alcohol dose.
Why it matters
It outlines how acute alcohol intake may antagonize the molecular signaling pathways that drive muscle protein synthesis following resistance exercise, pointing to specific modifying factors like feeding and sex.
Limits
The paper is a narrative review rather than a systematic review or meta-analysis. The abstract provides no specific study counts, sample sizes, or quantitative effect sizes, and notes that substantial gaps remain regarding sex-specific responses, dose-dependency, and nutritional interactions.
Cited by
- supports Alcohol consumption disrupts the activation of mTOR, impairing the signaling pathway that stimulates muscle protein synthesis.