The gut odorant receptor and taste receptor make sense of dietary components: A focus on gut hormone secretion.
Level 5 - mechanism / opinion, no new human data
Narrative review of mechanistic and preclinical research without human clinical trials.
PubMed 36785901 · doi:10.1080/10408398.2023.2177610
What was done
This narrative review summarizes research on how gastrointestinal chemosensory cells express odorant receptors (ORs) and taste receptors (TRs) to sense dietary components and metabolites, focusing on downstream regulation of gut hormone secretion.
What was found
The abstract reports no numerical data. It notes that gut cells express ORs and TRs (sweet, umami, and bitter receptors) that detect fatty acids, carbohydrates, and phytochemicals, leading to modulation of GLP-1, PYY, CCK, and 5-HT secretion.
Why it matters
Elucidating extra-oral chemoreceptor signaling in the gut outlines potential nutrient-sensing pathways that could be targeted for metabolic and gastrointestinal disorders.
Limits
As a narrative review, it lacks systematic search methodology and quantitative meta-analysis. The summarized findings rely heavily on mechanistic and preclinical evidence without direct human clinical data reported in the abstract.
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