Autonomic nervous system and cardiac neuro-signaling pathway modulation in cardiovascular disorders and Alzheimer's disease.
Level 5 - mechanism / opinion, no new human data
Narrative review describing mechanistic pathways without primary human data or systematic search methodology
PubMed 36798942 · doi:10.3389/fphys.2023.1060666
What was done
This narrative review summarized literature on autonomic nervous system regulation and cardiac neurotrophic signaling. The authors evaluated the pathophysiological mechanisms of cardiac nervous system impairment, maladaptive remodeling, and neurotrophin loss across cardiovascular disorders (such as myocardial infarction and heart failure) and Alzheimer's disease.
What was found
The abstract reports no quantitative data or numerical outcomes. It describes the physiological roles of sympathetic and parasympathetic signaling alongside neurotrophic factors in maintaining myocardial innervation, noting that pathway dysregulation and neurotrophin loss culminate in myocardial denervation in both cardiometabolic diseases and Alzheimer's disease.
Why it matters
It proposes a unified mechanistic framework linking central neurodegeneration in Alzheimer's disease to peripheral cardiac autonomic denervation, pointing to cardiac neuro-signaling pathways as possible therapeutic targets.
Limits
As a narrative review, it presents theoretical and mechanistic reasoning rather than systematic review methodology or new empirical human data. The abstract provides no details on study selection, sample sizes, or quantitative effect sizes.
Cited by
- supports Acetylcholine is the primary neurotransmitter used by the parasympathetic branch of the autonomic nervous system.