Ovarian aging in humans: potential strategies for extending reproductive lifespan.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic methodology or original human empirical data
PubMed 36913129 · doi:10.1007/s11357-023-00768-8
What was done
This narrative review synthesized existing knowledge on human ovarian aging, the physiological decline of ovarian reserve (antral follicle count and anti-Müllerian hormone), determinants of menopausal timing (genetics, diet, physical activity, and lifestyle), and the downstream impacts on fertility and post-menopausal disease risk. The authors formulated a set of criteria required for viable strategies to preserve ovarian reserve.
What was found
The abstract provides no quantitative data or effect sizes. It reports that genetics (family history) is the primary determinant of menopausal onset, with lifestyle and diet serving as modifiable factors. The authors define four theoretical criteria for ideal anti-ovarian aging interventions: initiation while ovarian reserve remains adequate, suitability for long-term maintenance, ability to regulate primordial follicle activation and atresia dynamics, and safety throughout pre-conception, pregnancy, and lactation.
Why it matters
Ovarian aging affects both early-life fertility and late-life chronic disease risk. Establishing specific criteria for interventions helps guide research toward clinically viable methods for extending reproductive lifespan.
Limits
The abstract describes a narrative review and presents no original patient data, quantitative meta-analyses, or systematic review methodology. Proposed strategies and criteria are conceptual and require validation in formal clinical trials.
Cited by
- supports Undergoing an IVF cycle or egg freezing does not decrease a woman's ovarian reserve or cause earlier onset of menopause.