The circadian neutrophil, inside-out.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic concepts and theoretical models without primary empirical human data or systematic review methodology.
PubMed 36999376 · doi:10.1093/jleuko/qiad038
What was done
This is a narrative review describing how cell-intrinsic and cell-extrinsic circadian rhythms regulate neutrophil physiology and function across immune defense and homeostatic roles. The authors also synthesize concepts from other cell types to theorize about unexplored areas in neutrophil topology, metabolism, and tissue clock regulation.
What was found
The abstract reports no empirical numbers or quantitative findings. It presents a conceptual framework of diurnal oscillations governing neutrophil biology and outlines theoretical relationships between rhythmic neutrophil behavior, cellular metabolism, and tissue-level circadian clocks.
Why it matters
It organizes current thinking on the intersection of chronobiology and innate immunity, highlighting how rhythmic neutrophil activity extends beyond infection defense to baseline tissue regulation.
Limits
As a non-systematic narrative review, it carries risk of selection bias and lacks quantitative synthesis. No primary clinical or experimental data are reported in the abstract, and several proposed mechanisms rely on extrapolation and speculation from non-neutrophil cell types.
Cited by
- context During sleep, tissues become populated by neutrophils originating from bone marrow that deposit collagen.