Investigating the Relationship between Obstructive Sleep Apnoea, Inflammation and Cardio-Metabolic Diseases.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic search methodology or original data.
PubMed 37047780 · doi:10.3390/ijms24076807
What was done
Narrative review synthesizing evidence and mechanistic pathways connecting obstructive sleep apnoea, intermittent hypoxia, circadian disruption, systemic inflammation, and obesity to cardiovascular and metabolic diseases, as well as the effects of CPAP therapy.
What was found
No quantitative data or metrics were reported in the abstract. The review qualitatively describes that intermittent hypoxia drives oxidative stress and inflammation, OSA shares a reciprocal relationship with obesity, and CPAP improves symptoms, reduces cardiovascular risk, and normalizes biomarkers.
Why it matters
This review integrates mechanistic links between sleep-disordered breathing and cardiovascular risk factors to outline therapeutic considerations for CPAP.
Limits
As a narrative review, it contains no primary data, systematic search protocol, or meta-analytic pooling. Specific sample sizes, populations, and effect sizes are absent from the abstract.
Cited by
- supports Untreated sleep apnea can lead to liver, kidney, and brain complications due to cellular oxygen stress.