Cohen · JAMA 2023 · analytical chemistry product survey · n=?

Quantity of Melatonin and CBD in Melatonin Gummies Sold in the US.

Cited 70 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Bench analytical chemistry testing of consumer products without human participants (by design analogy, not clinical CEBM)

PubMed 37097362 · doi:10.1001/jama.2023.2296 · record verified 2026-08-26

What was done

The study analyzed products marketed and sold in the United States as melatonin gummies to measure the actual quantities of melatonin and cannabidiol (CBD) compared with the quantities declared on their labels.

What was found

The abstract reports no numbers, percentages, or directional findings regarding how measured amounts compared to labeled amounts.

Why it matters

Accurate quantification of active ingredients in over-the-counter gummies is relevant for consumer safety and assessing label fidelity.

Limits

The abstract provides no sample size, testing methods, brand information, or quantitative outcomes. As a product assay, it did not measure clinical efficacy, bioavailability, or human health outcomes.

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