Ketogenic diet in therapy of bipolar affective disorder - case report and literature review.
Level 4 - case-series / case-control
Individual clinical case report with a narrative literature review
PubMed 37098202 · doi:10.12740/PP/OnlineFirst/136356
What was done
The authors presented a single case report of a male patient with bipolar affective disorder (BPAD) who had failed to achieve euthymia with lamotrigine monotherapy or combined treatment with quetiapine. The patient was placed on a ketogenic diet, accompanied by a narrative review of proposed neurobiological mechanisms.
What was found
Following the introduction of the ketogenic diet, the patient achieved full remission of the disorder, allowing for a reduction in lamotrigine dosage and the complete discontinuation of quetiapine. The abstract reports no numerical outcome scores, biomarker levels, or duration of follow-up.
Why it matters
It highlights the potential role of dietary metabolic interventions as an adjunctive strategy for individuals with treatment-resistant bipolar disorder, warranting formal clinical trials.
Limits
Findings are limited to a single uncontrolled case report (n = 1) and narrative review. No quantitative psychiatric rating scales, objective markers of ketosis, dietary adherence data, or follow-up timelines are reported in the abstract.
Cited by
- context Jan Baszucki's son with bipolar disorder experienced mood stabilization, cessation of mania and depression cycling, and improved sleep within weeks of adopting a ketogenic diet.