Mechanisms of spermidine-induced autophagy and geroprotection.
Level 5 - mechanism / opinion, no new human data
Narrative review and mechanism-based reasoning from preclinical animal models with no primary human data.
PubMed 37118547 · doi:10.1038/s43587-022-00322-9
What was done
This narrative review synthesizes literature on the molecular mechanisms of spermidine-induced autophagy and geroprotection across non-human model organisms (fungi, nematodes, insects, and rodents) and discusses strategies for clinical translation.
What was found
The abstract reports no numerical data. Qualitatively, it reports that spermidine prolongs lifespan in fungi, nematodes, insects, and rodents, and postpones the onset of age-associated disorders, including cardiovascular disease and neurodegeneration, in mice.
Why it matters
It outlines how dietary spermidine acts at the molecular level to delay aging pathways, providing a rationale for translational and clinical research in humans.
Limits
This is a non-systematic narrative review with an unstated number of included studies. All findings reported in the abstract derive from non-human model organisms, with no human efficacy, safety, or dosage data provided.
Cited by
- supports Spermidine extends the lifespan of every animal model it has been tested in, ranging from worms to mice.