Skeletal muscle memory.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic search or meta-analysis
PubMed 37154489 · doi:10.1152/ajpcell.00099.2023
What was done
This narrative review summarizes recent literature on the biological mechanisms of skeletal muscle memory. It examines cellular and epigenetic mechanisms, their potential synergy, positive and negative muscle memory concepts, and applications to training design and therapeutic strategies for age-related muscle loss or muscle-wasting conditions.
What was found
The abstract provides no empirical numbers or quantitative effect sizes. It qualitatively describes that prior exercise training can prime skeletal muscle to improve adaptation during subsequent retraining following periods of detraining or exercise cessation.
Why it matters
Elucidating muscle memory mechanisms helps explain long-term adaptations to exercise and identifies potential targets for treating sarcopenia and clinical muscle wasting.
Limits
This is a narrative review with no systematic search methodology, quality appraisal, or meta-analytic data synthesis. The abstract contains no primary data, participant numbers, or quantitative outcomes.
Cited by
- supports Muscle memory involves an epigenetic component.