Cognitive dysfunction in diabetes: abnormal glucose metabolic regulation in the brain.
Level 5 - mechanism / opinion, no new human data
Narrative review describing mechanistic pathways without original human data or systematic review methodology.
PubMed 37396164 · doi:10.3389/fendo.2023.1192602
What was done
This narrative review synthesized proposed pathophysiological mechanisms connecting diabetes to cognitive dysfunction, focusing on cerebral glucose metabolic regulation, insulin signaling, brain insulin resistance, oxidative stress, inflammation, and mitochondrial dysfunction.
What was found
The abstract reports no quantitative data or numerical outcomes. It qualitatively describes how disrupted brain glucose transport and cerebral insulin resistance impair synaptic transmission and neural plasticity, contributing to diabetic cognitive dysfunction.
Why it matters
The paper outlines mechanistic frameworks explaining how systemic metabolic abnormalities in diabetes may translate into impaired brain energy metabolism and neurocognitive decline.
Limits
The review provides theoretical and mechanistic reasoning rather than new empirical data or a systematic evidence synthesis. The abstract reports no sample size, search methodology, or quantitative findings.
Cited by
- supports Glucose is the major fuel for human cells and brain cells, directly affecting cognitive function, mood, and energy levels.