Anticancer properties of sulforaphane: current insights at the molecular level.
Level 5 - mechanism / opinion, no new human data
Narrative review summarizing molecular mechanisms without systematic review or meta-analytic methodology
PubMed 37397365 · doi:10.3389/fonc.2023.1168321
What was done
This narrative review searched PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar to summarize the molecular mechanisms underlying the anticancer potential of sulforaphane, an isothiocyanate derived from the hydrolysis of glucoraphanin in Brassica plants.
What was found
The authors report that broccoli sprouts are 20 to 50 times richer in sulforaphane than mature broccoli, providing approximately 1,153 mg/100 g. The review notes that sulforaphane alters multiple epigenetic and non-epigenetic pathways to confer anticancer effects and exhibits a favorable safety profile. No specific clinical trial outcome numbers or effect sizes are reported in the abstract.
Why it matters
It provides an overview of the molecular targets and dietary sources of sulforaphane, supporting its continued investigation as a chemopreventive phytochemical.
Limits
The abstract describes a broad narrative literature review rather than a systematic review or meta-analysis. It provides no clinical efficacy data, human outcome statistics, or established standardized dosing regimens.
Cited by
- supports When cruciferous vegetables containing glucoraphanin are crushed or chewed, an enzyme converts glucoraphanin into sulforaphane.