Developing Theoretical Models of Kinesia Paradoxa Phenomenon in Order to Build Possible Therapeutic Protocols for Parkinson's Disease.
Level 5 - mechanism / opinion, no new human data
Theoretical model and mechanism-based reasoning without empirical data
PubMed 37486479 · doi:10.1007/978-3-031-31982-2_6
What was done
The authors developed a theoretical framework based on three neural circuits hypothesized to mediate kinesia paradoxa (the temporary normalization of movement in Parkinson's disease) to outline potential therapeutic protocols.
What was found
The abstract reports no empirical data, sample sizes, statistical analyses, or experimental results. It describes only a conceptual outline linking proposed neural pathways to potential therapeutic guidelines.
Why it matters
Understanding the neural pathways underlying kinesia paradoxa could identify alternative motor circuits that bypass basal ganglia dysfunction in Parkinson's disease.
Limits
No human, animal, or bench experimental data are reported. The abstract does not specify which three neural circuits were evaluated or provide specific details regarding the proposed therapeutic protocols.
Cited by
- supports Individuals with Parkinson's disease experiencing akinesia or bradykinesia can suddenly execute rapid movements, such as running out of a burning house, when faced with an urgent emergency (kinesia paradoxa).