Current therapeutic targets and multifaceted physiological impacts of caffeine.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing molecular mechanisms, pharmacology, and physiological impacts without systematic methodology
PubMed 37679309 · doi:10.1002/ptr.8000
What was done
The authors synthesized literature on the molecular mechanisms, experimentally validated pharmacological targets, and organ-specific physiological and pathophysiological effects of caffeine.
What was found
The abstract reports no quantitative data or effect sizes. It summarizes that caffeine acts primarily as a nonselective adenosine receptor antagonist at physiological doses. It notes associations with beneficial outcomes in cardiovascular disease and type 2 diabetes, while highlighting dose-dependent paradoxical effects in humans, including hypertension versus hypotension and tachycardia versus bradycardia.
Why it matters
This review outlines the concentration-dependent molecular targets of caffeine to help explain how differing doses elicit divergent physiological responses across organ systems.
Limits
The abstract describes a narrative review without systematic search protocols, quality appraisal, or quantitative data synthesis. Specific effect sizes, population details, and underlying study designs are not reported in the abstract.
Cited by
- contradicts Adenosine and caffeine are separated in structure by only one molecule.