Dental Considerations and Precautions Associated with Oral Excisional Biopsy on a Patient with Cushing's Syndrome (Hypercortisolism).
Level 5 - mechanism / opinion, no new human data
Narrative review without primary empirical data or systematic methodology
PubMed 37714599 · doi:10.1016/j.cden.2023.05.005
What was done
This narrative clinical review outlines the etiology, epidemiology, and head and neck manifestations of Cushing's syndrome (hypercortisolism) relevant to dental management and oral excisional biopsy.
What was found
The abstract reports that endogenous Cushing's syndrome has an annual incidence of 0.2 to 5 individuals per million and is categorized as ACTH-dependent or ACTH-independent. Exogenous glucocorticoid therapy for autoimmune or inflammatory conditions is highlighted as the most common overall cause (iatrogenic Cushing's syndrome). Reported clinical manifestations in the head and neck include a moon-shaped face, acne flares, and hirsutism. The abstract reports no empirical procedural data or quantitative outcomes regarding oral excisional biopsy.
Why it matters
It highlights clinical features of hypercortisolism that dental practitioners must recognize to plan safe surgical interventions and prevent systemic or local complications.
Limits
The abstract contains no empirical trial data, complication rates, or specific biopsy management protocols. It represents a narrative overview with no described systematic review methodology or patient sample size.
Cited by
- supports Cushing's syndrome is most commonly an iatrogenic condition resulting from high-dose or prolonged corticosteroid use.