The human glucocorticoid receptor.
Level 5 - mechanism / opinion, no new human data
Narrative review / book chapter describing mechanisms without primary empirical data.
PubMed 37717993 · doi:10.1016/bs.vh.2023.06.005
What was done
This chapter summarizes existing literature on the molecular biology, computational-structural characteristics, expression, signaling pathways, and epigenetic aspects of the human glucocorticoid receptor in both normal physiology and pathological states.
What was found
The abstract reports that the glucocorticoid receptor is an almost ubiquitous hormone-activated transcription factor influencing the transcription of up to 20% of the mammalian genome. No original quantitative data, effect sizes, or statistical metrics are reported in the abstract.
Why it matters
It provides a consolidated mechanistic overview of how target tissues process endogenous and synthetic glucocorticoid signals, which is fundamental to endocrinology and pharmacology.
Limits
The work is a narrative chapter lacking a systematic review methodology, formal quality assessment, or original empirical measurements. Specific clinical or experimental outcomes cannot be evaluated from the abstract.
Cited by
- supports Cortisol binds to glucocorticoid and mineralocorticoid receptors, which translocate to the nucleus and alter the expression of approximately 20% of the human genome.